Angel Sanctuary by Kaori Yuki is possible the most epic manga tale I’ve read so far, with a story setting that spans multiple levels of heaven and hell as well as earth, and a complex interweaving of dozens of important characters whose pasts and motivations are pretty thoroughly explored. You might read on the back of the volumes that it’s about a brother and sister who fall in love with each other, and that does form the basis of the tale, but when they both die and are separated and must go literally through heaven and hell to find each other again, a lot of other stuff happens along the way.
Like any manga I tend to enjoy, this one is full of androgynous characters, especially of the effeminate male variety.
[Spoiler] I must say I was a little surprised at the ending because I fully expected Rosiel and Alexiel to be revealed as lovers just like Setsuna and Sara, but that didn’t happen.
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